Karl D Hardman : rechercher sur Z-Library

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1

An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability

Whitlow, Mare, Bell, Brian A., Feng, Sheau-Line, Filpula, David, Hardman, Karl D., Hubert, Steven L., Rollence, Michele L., Wood, James F., Schott, Margaret E., Milenic, Diane E., Yokota, Takashi, Sch

Journal:

Protein Engineering Design and Selection

Année:

1993

Langue:

english

Fichier:

PDF, 745 KB

english, 1993

2

ChemInform Abstract: P1,P2′-Linked Macrocyclic Amine Derivatives as Matrix Metalloproteinase Inhibitors.

James J.-W. Duan, Lihua Chen, Chu-Biao Xue, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Robert R. Copeland, Elizabeth C. Arner, Carl P. Decicco

Journal:

Année:

1999

Fichier:

PDF, 37 KB

1999

3

Potent carboxylate inhibitors of stromelysin containing P2′ piperazic acids and P1′ biaryl moeities

Robert J. Cherney, Carl P. Decicco, David J. Nelson, Li Wang, Dayton T. Meyer, Karl D. Hardman, Robert A. Copeland, Elizabeth C. Arner

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1997

Langue:

english

Fichier:

PDF, 301 KB

english, 1997

4

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Irina C. Jacobson, Prabhakar G. Reddy, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Elizabeth C. Arner, Robert A. Copeland, Carl P. Decicco, Ronald L. Magolda

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 256 KB

english, 1998

5

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Robert J. Cherney, Li Wang, Dayton T. Meyer, Chu-Biao Xue, Elizabeth C. Arner, Robert A. Copeland, Maryanne B. Covington, Karl D. Hardman, Zelda R. Wasserman, Bruce D. Jaffee, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 290 KB

english, 1999

6

P1, P2′-Linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

James J.-W. Duan, Lihua Chen, Chu-Biao Xue, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Robert R. Cope, Elizabeth C. Arner, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1999

Langue:

english

Fichier:

PDF, 292 KB

english, 1999

7

Probing the P3′ pocket of stromelysin with piperazic acid analogs

David A. Nugiel, Kim Jacobs, Carl P. Decicco, David J. Nelson, Robert A. Copeland, Karl D. Hardman

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 195 KB

english, 1995

8

Identification of a Selectivity Determinant for Inhibition of Tumor Necrosis Factor-α Converting Enzyme by Comparative Modeling

Zelda R Wasserman, James J.-W Duan, Matthew E Voss, Chu-Biao Xue, Robert J Cherney, David J Nelson, Karl D Hardman, Carl P Decicco

Journal:

Chemistry & Biology

Année:

2003

Langue:

english

Fichier:

PDF, 298 KB

english, 2003

9

Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding

Pantoliano, Michael W., Whitlow, Marc, Wood, Jay F., Dodd, Steven W., Hardman, Karl D., Rollence, Michele L., Bryan, Philip N.

Journal:

Année:

1989

Langue:

english

Fichier:

PDF, 1.89 MB

english, 1989

10

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

Duan, James J.-W., Chen, Lihua, Wasserman, Zelda R., Lu, Zhonghui, Liu, Rui-Qin, Covington, Maryanne B., Qian, Mingxin, Hardman, Karl D., Magolda, Ronald L., Newton, Robert C.

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 165 KB

english, 2002

11

Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors

Cherney, Robert J., Duan, James J.-W., Voss, Matthew E., Chen, Lihua, Wang, Li, Meyer, Dayton T., Wasserman, Zelda R., Hardman, Karl D., Liu, Rui-Qin, Covington, Maryanne B., Qian, Mingxin, Mandlekar,

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 219 KB

english, 2003

12

Manganese and calcium binding sites of concanavalin A

Karl D. Hardman, Ramesh C. Agarwal, Marvin J. Freiser

Journal:

Journal of Molecular Biology

Année:

1982

Langue:

english

Fichier:

PDF, 1.35 MB

english, 1982

13

Structure of concanavalin A at 2.4-Ang resolution

Hardman, Karl D., Ainsworth, Clinton F.

Journal:

Année:

1972

Langue:

english

Fichier:

PDF, 1.68 MB

english, 1972

14

Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors

Cherney, Robert J., Wang, Li, Meyer, Dayton T., Xue, Chu-Baio, Wasserman, Zelda R., Hardman, Karl D., Welch, Patty K., Covington, Maryanne B., Copeland, Robert A., Arner, Elizabeth C., DeGrado, Willia

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 76 KB

english, 1998

15

Complementarity of Combinatorial Chemistry and Structure-Based Ligand Design: Application to the Discovery of Novel Inhibitors of Matrix Metalloproteinases

Rockwell, Arlene, Melden, Mark, Copeland, Robert A., Hardman, Karl, Decicco, Carl P., DeGrado, William F.

Journal:

Journal of the American Chemical Society

Année:

1996

Langue:

english

Fichier:

PDF, 148 KB

english, 1996

16

Sultam Hydroxamates as Novel Matrix Metalloproteinase Inhibitors

Cherney, Robert J., Mo, Ruowei, Meyer, Dayton T., Hardman, Karl D., Liu, Rui-Qin, Covington, Maryanne B., Qian, Mingxin, Wasserman, Zelda R., Christ, David D., Trzaskos, James M., Newton, Robert C., D

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 91 KB

english, 2004

17

Design of a diffractometer and flow cell system for X-ray analysis of crystalline proteins with applications to the crystal chemistry of ribonuclease-S

Wyckoff, Harold W., Doscher, Marilynn, Tsernoglou, Demetrius, Inagami, Tadashi, Johnson, Louise N., Hardman, Karl D., Allewell, Norma M., Kelly, David M., Richards, Frederic M.

Journal:

Journal of Molecular Biology

Année:

1967

Langue:

english

Fichier:

PDF, 1.45 MB

english, 1967

18

New concepts in monoclonal antibody based radioimmunodiagnosis and radioimmunotherapy of carcinoma

Schlom, Jeffrey, Milenic, Diane E., Roselli, Mario, Colcher, David, Bird, Robert, Johnson, Syd, Hardman, Karl D., Guadagni, Fiorella, Greiner, John W.

Journal:

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

Année:

1991

Langue:

english

Fichier:

PDF, 1.14 MB

english, 1991

19

Structure of Concanavalin A at 4.25-angstrom Resolution

Karl D. Hardman, Mical K. Wood, Marianne Schiffer, Allen B. Edmundson and Clinton F. Ainsworth

Journal:

Proceedings of the National Academy of Sciences

Année:

1971

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1971

20

X-ray Crystal Structures of Candida a lbicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH Is Displaced by an Inhibitor

Whitlow, Marc, Howard, Andrew J., Stewart, David, Hardman, Karl D., Chan, Joseph H., Baccanari, David P., Tansik, Robert L., Hong, Jean S., Kuyper, Lee F.

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 846 KB

english, 2001

21

Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli

Pantoliano, Michael W., Bird, Robert E., Johnson, Syd, Asel, Eric D., Dodd, Steven W., Wood, Jay F., Hardman, Karl D.

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 2.28 MB

english, 1991

22

Structure of the concanavalin A-methyl α-D-mannopyranoside complex at 6-Å resolution

Hardman, Karl D., Ainsworth, Clinton F.

Journal:

Année:

1976

Langue:

english

Fichier:

PDF, 1.90 MB

english, 1976

23

Structures of nickel(II) and cobalt(II) carboxypeptidase A

Hardman, Karl D., Lipscomb, William N.

Journal:

Journal of the American Chemical Society

Année:

1984

Langue:

english

Fichier:

PDF, 286 KB

english, 1984

24

Roles of the Propeptide and Metal Ions in the Folding and Stability of the Catalytic Domain of Stromelysin (Matrix Metalloproteinase 3) †

Wetmore, Diana R., Hardman, Karl D.

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 499 KB

english, 1996

25

Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production

Xue, Chu-Biao, He, Xiaohua, Roderick, John, DeGrado, William F., Cherney, Robert J., Hardman, Karl D., Nelson, David J., Copeland, Robert A., Jaffee, Bruce D., Decicco, Carl P.

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 98 KB

english, 1998

26

Binding of nonpolar molecules by crystalline concanavalin A

Hardman, Karl D., Ainsworth, Clinton F.

Journal:

Année:

1973

Langue:

english

Fichier:

PDF, 697 KB

english, 1973

27

1.67-.ANG. X-ray structure of the B2 immunoglobulin-binding domain of streptococcal protein G and comparison to the NMR structure of the B1 domain

Achari, Aniruddha, Hale, Stephen P., Howard, Andrew J., Clore, G. Marius, Gronenborn, Angela M., Hardman, Karl D., Whitlow, Marc

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.41 MB

english, 1992

28

Molecular modelling of protein-carbohydrate interactions. Docking of monosaccharides in the binding site of concanavalin A

Imberty, Anne, Hardman, Karl D., Carver, Jeremy P., Perez, Serge

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 2.33 MB

english, 1991

29

1.85 Å structure of anti-fluorescein 4-4-20 Fab

Whitlow, Marc, Howard, Andrew J., Wood, Jay F., Voss, Edward W., Hardman, Karl D.

Journal:

Protein Engineering Design and Selection

Année:

1995

Langue:

english

Fichier:

PDF, 1.79 MB

english, 1995

30

Characterization of a Single-Chain T-Cell Receptor Expressed in Escherichia coli

William F. Soo Hoo, Michael J. Lacy, Lisa K. Denzin, Edward W. Voss, Jr., Karl D. Hardman and David M. Kranz

Journal:

Proceedings of the National Academy of Sciences

Année:

1992

Langue:

english

Fichier:

PDF, 1005 KB

english, 1992

31

Myo-inositol Binding Site of Concanavalin A

HARDMAN, KARL D., AINSWORTH, CLINTON F.

Journal:

Nature New Biology

Année:

1972

Fichier:

PDF, 419 KB

1972